Contents
What is gene co-occurrence?
We determine the interactions among human genes based on their frequency in the biomedical texts. The co-occurrence network generated by our system is analyzed to identify disease-gene associations. More specifically, we study cancer-related genes found in the co-occurrence network.
What are co occurring mutations?
Mutually exclusive and co-occurring oncogene mutations in human cancer. (A) Oncogene mutations were grouped together when they occurred within a given gene (e.g., ‘KRAS’ for all mutations in ‘KRAS’) or in the same functional domain of the encoded protein (e.g., ‘PIK3CA_KD’ for kinase domain mutations of PIK3CA).
What are the 3 types of genes?
Type I genes tend to be involved in immune response or sensory receptors while type III genes are involved in cell to cell signalling and type II genes are a complex mix of all three types.
What is word co-occurrence?
In linguistics, co-occurrence or cooccurrence is an above-chance frequency of occurrence of two terms (also known as coincidence or concurrence) from a text corpus alongside each other in a certain order. Co-occurrence can be seen an extension of word counting in higher dimensions.
What is gene interaction?
Genetic interaction is the set of functional association between genes. One such relationship is epistasis, which is the interaction of non-allelic genes where the effect of one gene is masked by another gene to result either in the suppression of the effect or they both combine to produce a new trait (character).
What is co word analysis?
Co-word analysis is a content analysis technique that uses patterns of co-occurrence of pairs of items (i.e., words or noun phrases) in a corpus of texts to identify the relationships between ideas within the subject ar- eas presented in these texts.
Can mutations neutral?
In population genetics, mutations in which natural selection does not affect the spread of the mutation in a species are termed neutral mutations. Neutral mutations that are inheritable and not linked to any genes under selection will either be lost or will replace all other alleles of the gene.
What is global co-occurrence count?
Global Co-Occurrence Statistics. The simplest way to capture co-occurrence counts is to use a co-occurrence matrix. To create a co-occurrence matrix, you go through a body of text setting a window size around each word. You then keep track of which words appear in that window.
What a serendipity means?
: the faculty or phenomenon of finding valuable or agreeable things not sought for also : an instance of this.
What is gene interaction with example?
A simple, yet striking, example of gene interaction is the inheritance of skin coloration in corn snakes. The natural color is a repeating black-and-orange camouflage pattern, as shown in Figure 4-11a. The phenotype is produced by two separate pigments, both of which are under genetic control.
Which is the best description of a co-occurring disorder?
Co-Occurring Disorders. A person with a co-occurring disorder has been diagnosed with a substance abuse disorder and another mental health disorder. Co-occurring disorders, sometimes called dual disorders, are best treated through integrated treatment that addresses both issues at the same time.
Why is stigma a problem with co-occurring disorders?
Stigma and Other Issues Involving Co-Occurring Disorders Stigma is the greatest barrier to helping individuals with mental illness. Many people mistakenly think that people with mental illness are dangerous or that people with substance use disorders have a moral failing. In fact, the majority of people with mental illness pose no threat to others.
Are there any disorders that co-occur with substance abuse?
Mental Disorders that Co-Occur with Substance Abuse. Any mental health disorder can co-occur alongside substance use disorders. The most common types of co-occurring disorders include mood, anxiety, psychotic, eating, personality and behavioral disorders.