Contents
What is gene expression what can affect gene expression?
Gene expression is the process by which the instructions in our DNA are converted into a functional product, such as a protein. It acts as both an on/off switch to control when proteins are made and also a volume control that increases or decreases the amount of proteins made.
What is selective gene expression?
Selective expression of a gene product (mRNA or protein) is a pattern in which the expression is markedly high, or markedly low, in one particular tissue compared with its level in other tissues or sources.
What contributes to gene expression?
Internal and external environmental factors, like gender and temperature, influence gene expression. Similarly, drugs, chemicals, temperature, and light are among the external environmental factors that can determine which genes are turned on and off, thereby influencing the way an organism develops and functions.
How is gene expression used to identify visceral organ metastases?
Identification of a gene expression profile in tumours that selects a subpopulation of patients that is more likely to develop visceral organ metastases will help elucidate mechanisms for the development of distant metastases and could be of clinical value.
How many genes are involved in lung metastasis?
The gene expression signature (consisting of 54 genes) predicting lung metastases identified by Minn et al. [ 11] identified 55 primary tumours as having a “lung metastasis” gene expression signature. Out of the 55 tumours which positively tested for this signature, 17 (30.9%) were found to have developed lung metastases.
Connect and share knowledge within a single location that is structured and easy to search. DNA microarrays are used to measure the expression levels of large numbers of genes simultaneously. Learn more…