What are cluster biomarkers?
Cluster analysis can group individuals based on heterogeneity within a single biomarker, or an array of biomarkers; therefore, multiple co-occurring pathological features can simultaneously be captured in a single clustering, making it a particularly promising approach for detecting groups of individuals who may be on …
What is patient clustering?
Cluster analysis using a k-means method was used to identify subgroups of patients based on their responses to the Patient-Physician Discordance Scales (PPDS), an instrument that assesses perceptions of health status and of the clinical visit.
How is clustering used to identify a biomarker?
This study aims to select combinatorial miRNA biomarkers, which have higher sensitivity and specificity than single-gene biomarkers. In order to avoid exhaustive search and redundant information, miRNAs are firstly clustered, then the combinations of representative cluster members are assessed as potential biomarkers.
How is a clustering-based approach for efficient identification?
Our experimental results demonstrate that the clustering-based method can identify microRNA combinatorial biomarkers with high accuracy and efficiency. Our method and data are available to the public upon request. MicroRNAs (miRNAs) play important regulatory roles in many fundamental biological processes for disease development and progression.
How are microRNAs used as tumor biomarkers?
MicroRNAs (miRNAs) have great potential serving as tumor biomarkers and therapeutic targets. As the rapid development of high-throughput experimental technology, gene expression experiments have become more and more specialized and diversified. The complex data structure has brought great challenge for the identification of biomarkers.
How is clustering used to find co-expressed genes?
Clustering approaches have been extensively used to find co-expressed genes. Genes in the same clusters are usually functionally related. There have been some studies that adopted clustering-based methods for feature selection.