Contents
What is an IPD meta-analysis?
IPD meta-analysis is a specific type of systematic review. Rather than extracting summary (aggregate) data from study publications or from investigators, the original research data are sought directly from the researchers responsible for each study.
What is sensitivity analysis in meta-analysis?
A sensitivity analysis is a repeat of the primary analysis or meta-analysis, substituting alternative decisions or ranges of values for decisions that were arbitrary or unclear. There are many decision nodes within the systematic review process which can generate a need for a sensitivity analysis.
How long does it take to do an IPD meta-analysis?
IPD meta-analyses take more time to complete (several years), cost significantly more (to cover cost of personnel, data housing, data cleaning and harmonization), and can face more challenges in obtaining the data (original study investigators must agree to share original data) than meta-analyses of AD (Cooper and Patall, 2009; Riley et al. 2010).
Which is the best meta-analysis of AD IPD?
Summary of Comparisons of Approaches Meta-Analysis of AD IPD Meta-Analysis/Retrospective Pooled A Prospectively Planned Pooled Analysis Length of Time to Complete Short Long Long Expense Low High High Control over Data Low High Highest Concern for Publication Bias High N/A N/A
What is the purpose of an individual participant meta-analysis?
Individual Participant Data (IPD) Meta-Analysis (Pooled Analyses) Purpose: The individual participant data (IPD) meta-analysis, also known as a retrospective pooled analysis, uses statistical analyses to generate a summary estimate using individual participant data from published and unpublished studies.
How to conduct a meta-analysis of aggregate data?
Steps of a Meta-Analysis of Aggregate Data: 1. Conduct a systematic review of the literature: The first step in conducting a meta-analysis of AD is to conduct a systematic review. A systematic review is primarily focused on identifying all of the available, relevant studies that are related to a specific and well-defined question of interest.